Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction,
英文名:
Rho Kinase Inhibitor IV
库存:
1 mg, 10 mg, 5 mg, 500 µg
供应商:
Cayman
CAS号:
913844-45-8
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
A selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK2); poorly inhibits CaMKII, PKG, and Aurora A (IC50 = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC50 ≥10 μM for each)