Metformin is a biguanide with diverse biological activities.{21403,13720,43272,43273} Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and hig
英文名:
1,1-Dimethylbiguanide hydrochloride
库存:
1 g, 5 g
供应商:
Cayman
CAS号:
1115-70-4
A biguanide with diverse biological activities; increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice at 250 mg/kg; reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice at 10 or 50 mg/kg per day; reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in an ob/ob mouse model of NAFLD; reduces tumor growth in an HCT116 p53-\- mouse xenograft model at 250 mg/kg