Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins.{20554,20553,20549} Inhibition of PARP activity has b
英文名:
AG-014699|PF-01367338
库存:
1 mg, 10 mg, 5 mg
供应商:
Cayman
CAS号:
459868-92-9
A potent, cell-permeable inhibitor of PARP1 (Ki = 50s = 1.3-5.5 μM); arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors