Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2
英文名:
Tryptoquivaline
库存:
1 mg, 250 µg
供应商:
Cayman
CAS号:
118974-02-0
A specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter; at 5 μM, significantly potentiates the toxicity of chemotherapeutic drugs in colon carcinoma cells; reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1)