In addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface.{19632,19633} Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 b
英文名:
2-Phenylethynesulfonamide|PFT-μ
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
64984-31-2
An inhibitor of p53-mediated apoptosis, preventing p53 binding at the mitochondrial surface without affecting p53 transactivational activities; at 25 μM, pifithrin-μ reduces p53-mediated apoptosis triggered by nutlin; also interacts selectively with Hsp70, disrupting its association with many substrate proteins