Polybiquitinylation designates proteins for proteasomal degradation. USP14 is one of several deubiquitinating enzymes (DUBs) responsible for shortening proteasome-bound ubiquitin chains, which is known to antagonize the degradation of ubiquitin-protein c
库存:
10 mg, 100 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
314245-33-5
A reversible, small molecule inhibitor of USP14 deubiquitination (IC50 = 4-5 μM); stimulates ubiquitin-dependent protein degradation in vitro (34 μM) and in cells (50 μM); reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress