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N-Octadecanoyl-D35-psychosine, (perdeuterated, C18:0 fatty acid)
大量
上海惠诚生物科技有限公司
145176-92-7
5 mg
Specifications
Catalog #:1914
Scientific Name:N-Octadecanoyl-D35-psychosine (perdeuterated, C18:0 fatty acid)
Common Name:N-C18:0-D35-Cerebroside, perdeuterated; N-Stearoyl-D35-psychosine, perdeuterated
Empirical Formula:C42H46D35NO8
CAS#:145176-92-7
SDS:View Safety Data Sheet
Data Sheet:View Data Sheet
Formula Weight:763
Unit:5 mg
Solvent:none
Source:semisynthetic
Purity:98+%
Analytical Methods:TLC, identity confirmed by MS
Natural Source:bovine
Solubility:chloroform, hot ethanol, chloroform/methanol, 2:1
Physical Appearance:solid
Storage:-20℃
Composition:Deuterium labeled stearoyl sidechain
Dry Ice:No
Hazardous:No
Description
Application Notes:
这种脑苷类产品是一种糖鞘磷脂,含有半乳糖(半乳糖脑苷),与C18:0过氘脂肪酸酰基化的神经酰胺相连,使其成为质谱的理想标准品。半乳糖脑苷主要存在于神经组织中,是中枢神经系统中主要的鞘糖脂。它们是神经髓鞘中最大的单一组成部分,似乎与其他分子一起构成了髓鞘结构支撑的一部分脑苷参与细胞凝集、细胞内通讯、细胞发育和抗肿瘤/细胞毒作用等非常广泛的生物活性半乳糖-脑苷可代谢为硫化物,在神经系统和髓鞘中也大量存在。由于脑侧体的熔点相对较高(远高于生理体温),它们具有准晶体结构。克拉布病(球形细胞脑白质营养不良症)的特征是半乳糖脑苷酶缺乏,这种酶负责降解半乳糖脑苷。这导致脑苷和精神素的积累(这是非常细胞毒性,可导致神经脱髓鞘和轴突传导丧失)。本标准品适用于克拉布病研究及其他研究中脑苷的鉴定和分离。
This cerebroside product is a glycosphingolipid containing a galactose (galactocerebroside) attached to a ceramide acylated with a C18:0 perdeuterated fatty acid, making it an ideal standard for mass spectrometry. Galactocerebrosides are found primarily in neuronal tissues and are the major glycosphingolipids in the central nervous system. They are the largest single component of the myelin sheath of nerves and seem to act, along with other molecules, to form part of the structural support of the myelin sheath.1 Cerebrosides are involved in a very wide range of biological activities such as cell agglutination, intracellular communication, cellular development, and antitumor/cytotoxic effects.2 Galactocerebroside can be metabolized into sulfatide which is also abundant in the nervous system and myelin sheaths. Due to the relatively high melting point of cerebrosides (much greater than physiological body temperature) they have a para-crystalline structure. Krabbe’s disease (globoid cell leukodystrophy) is characterized by a deficiency in the enzyme galactocerebrosidase, which is responsible for degrading galactocerebroside. This leads to an accumulation of cerebroside and psychosine (which is very cytotoxic and can result in demyelination of nerves and loss of axonal conductivity). This standard from Matreya is excellent for use in the identification and isolation of cerebrosides in the study of Krabbe’s disease and other studies.3
References:
1. M. Sheldon, D.Lyudmila, “Cycloserine-induced decrease of cerebroside in myelin” Lipids, Vol. 33:4 pp. 441-443, 1998
2. X. Zhou, L. Tang and Y. Liu “An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells” Lipids, Vol. 44:8 pp. 759-763, 2009
3. X. Han and H. Cheng “Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics” Journal of Lipid Research, Vol. 46 pp. 163-175, 2005
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