This product is a high purity phosphorylcholine (PC) that is acylated at the sn-1 and -2 positions with stearic acid, forming a phosphorylcholine that is common in many animals and is therefore useful as a standard.1 PC is a major component of biological membranes, especially in the outer leaflet, often composing almost 50% of the total phospholipids.2 It is a vital component in membrane bilayers and is the main phospholipid circulating in plasma. PC plays an important role in membrane-mediated cell signaling by generating diacylglycerols and phospholipids.3 Phospholipase D is an enzyme that cleaves off the choline head group, converting PC to phosphatidic acid, while phospholipase C cleaves off the phosphate group leaving diacylglycerol. PC is the biosynthetic precursor of sphingomyelin, phosphatidylethanolamine, lysophosphatidylcholine, and platelet-activating factor. The choline headgroup is an essential nutrient in animals although it can be synthesized by methylating phosphatidylethanolamine to phosphatidylcholine and then cleaving the headgroup with phospholipase D.4 Tumor cells appear to have increased synthesis of PC and this may be a potential target for cancer therapy. Another function of PC is the activation of enzymes such as the enzyme 3-hydroxybutyrate dehydrogenase which must be bound to phosphatidylcholine before it can function optimally.
References: 1. E. Sim, P. Cullis, and R. Richards “Physical Studies on Phosphonium Phosphafidylcholine” Journal of Biochemistry, vol. 151 pp. 555-560, 1975
2. M. Billah and J. Anthes “The regulation and cellular functions of phosphatidylcholine hydrolysis” Biochemistry Journal, Vol. 269 pp. 281-291, 1990
3. J. Exton “Signaling through Phosphatidylcholine Breakdown” The Journal of Biological Chemistry, Vol. 265(1) pp. 1-4, 1990
4. Z. Li and D. Vance “Phosphatidylcholine and choline homeostasis” Journal of Lipid Research, Vol. 49 pp. 1187-1194, 2008
Matreya,LLC是一家油脂生化公司,提供综合系列的鞘脂、糖脂、神经节苷脂、球三糖神经酰胺、脂肪酸和甾醇。我们在高纯度产品和专门的技术援助方面享有可靠的声誉。 Matreya致力于开发和制造的脂质和生化物质。我们提供高质量的化学合成和天然产物的提取和纯化。惠诚生物把Matreya已经引入到国内市场,大量现货销售及产品服务。 This product is a high purity phosphorylcholine (PC) that is acylated at the sn-1 and -2 positions with stearic acid, forming a phosphorylcholine that is common in many animals and is therefore useful as a standard.1 PC is a major component of biological membranes, especially in the outer leaflet, often composing almost 50% of the total phospholipids.2 It is a vital component in membrane bilayers and is the main phospholipid circulating in plasma. PC plays an important role in membrane-mediated cell signaling by generating diacylglycerols and phospholipids.3 Phospholipase D is an enzyme that cleaves off the choline head group, converting PC to phosphatidic acid, while phospholipase C cleaves off the phosphate group leaving diacylglycerol. PC is the biosynthetic precursor of sphingomyelin, phosphatidylethanolamine, lysophosphatidylcholine, and platelet-activating factor. The choline headgroup is an essential nutrient in animals although it can be synthesized by methylating phosphatidylethanolamine to phosphatidylcholine and then cleaving the headgroup with phospholipase D.4 Tumor cells appear to have increased synthesis of PC and this may be a potential target for cancer therapy. Another function of PC is the activation of enzymes such as the enzyme 3-hydroxybutyrate dehydrogenase which must be bound to phosphatidylcholine before it can function optimally.上海惠诚生物专业优势供应Matreya磷脂类标准品 ,每周三和国外下单,2周到货。更多关于Matreya品牌脂类标准品,欢迎拨打惠诚生物客户服务电话18017273415