Specifications
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Catalog #:1248
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Scientific Name:9(Z),11(Z)-Octadecadienoic acid
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Common Name:9-cis, 11-cis-CLA
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Empirical Formula:C18H32O2
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CAS#:544-70-7
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SDS:View Safety Data Sheet
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Data Sheet:View Data Sheet
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Formula Weight:280
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Unit:25 mg
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Source:synthetic
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Purity:96+%
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Analytical Methods:GC; TLC; identity confirmed by MS
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Melting Point:40-42°C
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Solubility:ethanol, methanol, chloroform, ethyl ether
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Physical Appearance:solid
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Storage:-20℃
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Dry Ice:No
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Hazardous:No
Application Notes:
9(Z),11(Z)-十八碳二烯酸是共轭亚油酸(CLA),是亚油酸的异构体。共轭亚油酸主要存在于包括乳制品在内的反刍动物的脂质中。它具有多种生物学特性,包括抗癌活性,抑制人体黑色素瘤、结直肠癌和乳腺癌细胞的体外生长,并表现出抗动脉粥样硬化活性人们认为CLA本身可能不具有抗氧化能力,但可能产生保护细胞免受过氧化物伤害的物质。由于它是一个次要组分,它非常有助于比较主要的异构体9(Z),11(E)-CLA和10(E),12(Z)-CLA。9(Z),11(Z)-CLA已被证明具有比更常见的9(Z),11(E)-CLA异构体更强的抗增殖作用,与人结肠癌细胞孵育。
9(Z),11(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals including dairy products. It has several biological properties including anticarcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Due to its being a minor component it is very helpful as a comparison to the major isomers 9(Z),11(E)-CLA and 10(E),12(Z)-CLA. 9(Z),11(Z)-CLA has been demonstrated to have a more potent antiproliferative effect than the more common 9(Z),11(E)-CLA isomer when incubated with human colon cancer cells.
References:
1. Helen B. MacDonald, Journal of the American College of Nutrition, Vol. 19, No. 90002, 111S-118S, 2000
2. Mairéad Coakley, Mark C. Johnson, Emma McGrath, Shafiqur Rahman, R. Paul Ross, Gerald F. Fitzgerald, Rosaleen Devery, Catherine Stanton, Nutrition and Cancer, 56(1) pp. 95-102, 2006
Matreya,LLC是一家油脂生化公司,提供综合系列的鞘脂、糖脂、神经节苷脂、球三糖神经酰胺、脂肪酸和甾醇。我们在高纯度产品和专门的技术援助方面享有可靠的声誉。 Matreya致力于开发和制造的脂质和生化物质。我们提供高质量的化学合成和天然产物的提取和纯化。惠诚生物把Matreya已经引入到国内市场,大量现货销售及产品服务。 9(Z),11(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals including dairy products. It has several biological properties including anticarcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Due to its being a minor component it is very helpful as a comparison to the major isomers 9(Z),11(E)-CLA and 10(E),12(Z)-CLA. 9(Z),11(Z)-CLA has been demonstrated to have a more potent antiproliferative effect than the more common 9(Z),11(E)-CLA isomer when incubated with human colon cancer cells.上海惠诚生物专业优势供应Matreya磷脂类标准品 ,每周三和国外下单,2周到货。更多关于Matreya品牌脂类标准品,欢迎拨打惠诚生物客户服务电话18017273415