Recombinant Human CD81 (N-FC)

Recombinant Human CD81 (N-FC) (C08A)

 

产品说明(Description)

Recombinant Human CD81 antigen is produced by our Mammalian expression system and the target gene encoding Phe113-Lys201 is expressed with a Fc tag at the N-terminus.

Accession #: P60033

Known as: CD81 antigen; CD81 molecule; CD81; CVID6; TAPA1; TAPA-1; TSPAN28

 

制剂(Formulation)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

 

质量控制(Quality Control)

Purity: Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

复溶(Reconstitution)

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

 

保存(Storage)

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.

Reconstituted protein solution can be stored at 4-7°C for 2-7 days.

Aliquots of reconstituted samples are stable at < -20°C for 3 months.     

 

背景(Background)

CD81, also known as TAPA-1 and Tetraspanin-28, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. CD81 associates with a wide range of membrane proteins including CD151, TfR2, LDL R, PCSK9, Glypican 3, IFITM1, IGSF8/CD316, FPRP, and complexes of CD19-CD21. It is related to adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. CD81 additionally functions as a receptor for the E2 glycoprotein of hepatitis C virus. The CD81-E2 interaction inhibits NK cell cytolytic activity, provides a co-stimulatory signal to T cells, and inhibits the maturation of plasmacytoid dendritic cells.

 

电泳(SDS-PAGE)

 

FOR RESEARCH USE ONLY