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文献和实验Characterization of Angiotensin II Receptors
. Christ, D.D. 1995. Human plasma protein binding of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) and its pharmacologically active metabolite EXP3174. J. Clin. Pharmacol. 35:515‐520
Gene Therapy for Hypertension: Antisense Inhibition of the Renin-Angiotensin System
to be overactive in hypertension and that are proven targets of current drug treatments. These include β1-receptors, angiotensin-converting enzyme (ACE), and angiotensin type 1 receptors (AT1R). Antisense oligonucleotides are short (12-20 bases), single strands
Cardiac-Specific Overexpression of Angiotensin II Type 1 Receptor in Transgenic Rats
This chapter describes the methods required for overexpression of the angiotensin II type I receptor (AT1 ) in cardiomyocytes of transgenic rats. This includes cloning of the transgenic construct consisting of the α-myosin heavy chain (MHC
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