CD11a (human) monoclonal antib

【翻译】Development trends for monoclonal antibody cancer therapeutics

). However, since 2000, humanized and human mAbs have been entering clinical study at approximately the same rate (4.3 versus 4.5 mAbs per year, respectively). Figure 1 | Categories of monoclonal antibody cancer therapeutics entering clinical study during 1980–1989

Technology and Production of Murine Monoclonal and Recombinant Antibodies and Antibody Fragments

production described by K�hler and Milstein in 1975 (1 ). In the last 30 yr a number of genetically engineered antibody constructions have emerged, including chimeric and human-like antibodies as well as different antibody fragments. Nowadays, 18 rnAb

杂交瘤技术又称单克隆抗体技术(monoclonal antibody technique)

1975年，Kohler和Milstein发现将小鼠骨髓瘤细胞和绵羊红细胞免疫的小鼠脾细胞进行融合，形成的杂交细胞既可产生抗体，又可无限增殖，从而创立了单克隆抗体杂交瘤技术。这一技术上的突破不仅为医学与 生物 学基础研究开创了新纪元，也为临床疾病的诊断、预防和治疗提供了新的方法。     1. 杂交瘤的基本原理　杂交瘤技术又称单克隆抗体技术(monoclonal antibody technique)。杂交瘤技术是使免疫