VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1 Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality, and type II collagen-induced arthritis in mouse models.1 Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2 Modulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3 Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4 VGX-1027(6501-72-0)是一种免疫调节剂,可抑制LPS刺激的小鼠巨噬细胞分泌IL-1β、TNF-α和IL-10,并保留T细胞功能 改善急性和慢性免疫炎症条件的过程,如角叉菜胶诱导的胸膜炎,lps诱导的致死性和II型胶原诱导的小鼠模型关节炎 预防NOD小鼠模型中自发性和加速形式的自身免疫性糖尿病 在小鼠狼疮模型中调节脂多糖诱导toll样受体4激活的相关基因 通过阻断TLR4信号通路在颗粒物诱导的急性肺损伤中显示保护作用 。
References/Citations:
1) Stojanovic et al. (2007), In vitro, ex vivo and in vivo immunopharmacological activities of the isooxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models; Clin. Immunol., 123 311 2) Stosic-Grujisic et al. (2007), A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice; J. Pharmacol. Exp. Ther., 320 1038 3) Fagone et al. (2014), VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus; Immunology, 142 594 4) Xu et al. (2019), Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness; Eur. J, Pharmacol., 842 373
CAS:
6501-72-0
Catalog Number:
10-3409
Activity:
Immunomodulator; Cytokine release inhibitor
Chemical Name:
4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Alternate Name:
GIT 27
Molecular Weight:
205.21
Molecular Formula:
C11H11NO3 Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
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