Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced by Pseudomonas fluorescens.1 Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A, the toxic and effective doses were much lower. Safracin B also prolonged the life of tumor-bearing mice to a greater extent than safracin A.2 抗癌药物红花素B(87578-99-2)是由荧光假单胞菌产生的红花霉素家族的一种新型抗生素 红花素B对L1210、P388白血病和B16黑色素瘤具有抗肿瘤活性。 与藏红花素A相比,其毒性和有效剂量均较低。 在延长荷瘤小鼠寿命方面,藏红花素B比藏红花素a更明显。
References/Citations:
1) Ikeda et al. (1983), Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation; J. Antibiot. Tokyo, 36 1279 2) Okumoto et al. (1985), Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice; J. Antibiot.Tokyo, 38 767
CAS:
87578-99-2
Catalog Number:
10-3208
Activity:
Anticancer agent
Source:
Produced by Pseudomonas fluorescens Molecular Weight:
540.61
Molecular Formula:
C28H36N4O7 Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Yellow-green solid
Purity:
90% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
更多产品咨询联系 上海惠诚生物科技有限公司 联系人:任经理 电话:18017273415