8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1 It is a critical biomarker for oxidative stress and carcinogenesis.2,3 8-Oxo-2 ' -脱氧鸟苷(88847-89-6)是通过多种氧化过程损伤DNA的有用标记物 它是氧化应激和致癌的重要生物标志物。
References/Citations:
1) Beckman et al. (1997), Oxidative decay of DNA; J. Biol. Chem., 272 19636 2) Andreoli et al. (2010), Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers, 15 221 3) Manini et al. (2009), Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett., 190 41
CAS: 88847-89-6 Catalog Number: 10-2690 Activity: Marker for DNA damage Alternate Names: 8-Oxo-dG; Oxo-dG Chemical Name: 8-Oxo-7,8-dihydro-2′-deoxyguanosine Molecular Weight: 283.25 Molecular Formula: C10H13N5O5 Solubility: Soluble in DMSO (up to 10 mg/ml). Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) Storage Temperature: -20°C Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Shipping Code: RT