Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex.1,2 Arrests cell cycle at G2/M phase. Stimulates the intrinsic GTPase activity of tubulin.3 Nocodazole activates the JNK/SAPK signaling pathway and induces apoptosis in a variety of cell lines.4 Cell permeable. 微管抑制剂诺可达唑(31430-18-9)是一种抗有丝分裂剂,通过与β微管蛋白结合而破坏微管,从而抑制微管动力学、有丝分裂纺锤体功能的破坏和高尔基复合体的破碎。 1,2在G2/M期阻滞细胞周期。 2 .刺激小管蛋白固有的GTPase活性 诺可达唑可激活JNK/SAPK信号通路,诱导多种细胞系凋亡 细胞的渗透。
References/Citations:
1) Jordan et al. (1992), Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; J. Cell Science, 102 401 2) Storrie et al. (1998), Dynamics of the interphase mammalian Golgi complex as revealed through drugs producing reversible Golgi disassembly; Biochim. Biophys. Acta, 1404 127 3) Mejillano et al. (1996), Studies on the nocodazole-induced GTPase activity of tubulin; Arch. Biochem. Biophys., 336 130 4) Wang et al. (1998), Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways; J. Biol. Chem., 273 4928
CAS:
31430-18-9
Catalog Number:
10-2387
Activity:
Microtubule inhibitor
Alternate Names:
R-17934
Chemical Name:
Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Molecular Weight:
301.32
Molecular Formula:
C14H11N3O3S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
更多产品咨询联系 上海惠诚生物 联系人:任经理 电话:18017273415