Gambogic acid (2752-65-0) induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 mM)1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFb1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4 藤黄酸(2752-65-0)作为Bcl-2家族蛋白的拮抗剂(IC50 < 1 mM)1诱导多种细胞系的凋亡,但其他靶点可能有助于其细胞毒性。 通过抑制tgfb1诱导的上皮-间质转化来抑制肿瘤的侵袭和迁移 增强癌细胞对其他药剂的化学敏感性 降低存活,逆转肿瘤细胞对多西他赛的耐药性。
References/Citations
1) Zhai et al. (2008), Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins; Mol. Cancer Ther. 7 1639 2) Zhao et al. (2017), Gambogic acid suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition; Oncotarget 8 27120 3) Wei et al. (2017), Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis; Exp. Ther. Med. 13 662 4) Wang et al. (2008), Gambogic acid, a potent inhibitor of surviving, reverses docetaxel resistance in gastric cancer cells; Cancer Lett. 262 214
CAS:
2752-65-0
Catalog Number:
10-2188
Activity:
Bcl-2 family protein antagonist/Survivin inhibitor
Molecular Weight:
628.75
Molecular Formula:
C38H44O8 Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 50 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
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