Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable. Celastrol(34157-83-0)显示出强大的抗氧化和抗炎活性。 抑制NFkB (IC50=270 nM)。 它在各种细胞中诱导热休克反应和细胞保护。 抑制20S蛋白酶体凝乳胰蛋白酶活性(IC50=2.5 mM)。 3 .靶向AR/miR-101诱导前列腺癌细胞自噬 诱导肿瘤细胞upu依赖性细胞死亡 细胞的渗透。
References/Citations:
1) Sethi et al. (2007), Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κC-regulated gene products and TAK1-mediated NF-κB activation; Blood, 109 2727 2) Westerheide et al. (2004), Celastrols as inducers of the heat shock response and cytoprotection; J. Biol. Chem., 279 56053 3) Yang et al. (2006), Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine” is a potent proteasome inhibitor and suppresses human prostate cancer cell growth in nude mice; Cancer Res., 66 4758 4) Guo et al. (2015), Celastrol Induces Autophagy by targeting AR/miR-101 in Prostate Cancer Cells; PLoS One, 10(10) e0140745 5) Fribley et al. (2015), Celastrol induces unfolded protein response-dependent cell death in head and neck cancer; Exp. Cell Res., 330 412
CAS:
34157-83-0
Catalog Number:
10-2187
Activity:
Proteasome inhibitor
Chemical Name:
(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Molecular Weight:
450.62
Molecular Formula:
C29H38O4 Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
Red Solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
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