PD-98059 (167869-21-8) is an inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM).1,2 PD-98059 accelerates differentiation of RAW264.7 cells into osteoclast-like cells.3 Mimics BMP4 in supporting self renewal of embryonic stem cells.4 PD-98059(167869-21-8)是一种丝裂原激活蛋白激酶(MKK / MEK)抑制剂。 通过与灭活的MEK结合,阻止其被cRAF或MEK激酶磷酸化(IC50=2-7μM)。 1,2 PD-98059促进RAW264.7细胞向破骨细胞样细胞的分化 模拟BMP4支持胚胎干细胞的自我更新。
References/Citations:
1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489 2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686 3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366 4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027
CAS:
167869-21-8
Catalog Number:
10-2159
Activity:
MEK inhibitor
Alternate Names:
2′-Amino-3′-methoxyflavone
Chemical Name:
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Molecular Weight:
267.29
Molecular Formula:
C16H13NO3 Solubility:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
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