H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2
1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261 2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297
CAS:
127243-85-0
Catalog Number:
10-2144
Activity:
PKA inhibitor
Chemical Name:
N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
Molecular Weight:
519.28
Molecular Formula:
C20H20BrN3O2S • 2HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Water (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
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