Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1 Does not inhibit PKC (at concentrations <100 mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4. Ro 31-6045(113963-68-1)是一种双吲哚马来酰亚胺衍生物,是分裂原刺激蛋白激酶p70 (S6K)的有效抑制剂,独立于其上游激活剂mTOR.1发挥作用 不抑制PKC(浓度<100 mM),因此可以作为双吲哚马来酰亚胺PKC抑制剂s2(如GF 109203X3)和其他结构相关抑制剂的阴性对照 。
References/Citations:
1) Marmy-Conus et al. (2002), Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett., 519 135 2) Harmon et al. (1997), Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol., 10 71 3) Toullec et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem., 266 15771 4) Davis et al. (1992), Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem., 35 177
CAS:
113963-68-1
Catalog Number:
10-1603
Activity:
RKIP/Raf-1 kinase disruptor
Chemical Names:
1-Methyl-3,4-bis(indol-3-yl)maleimide
Molecular Weight:
341.36
Molecular Formula:
C21H15N3O2 Solubility:
Soluble in DMSO (35 mg/ml); ethanol (9 mg/ml)
Physical Properties:
Orange solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
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