JNK inhibitor IX (312917-14-9) inhibits JNK2 and JNK3 via binding to the ATP binding domain. Displays little or no activity against JNK1, p38α and a panel of 30 other kinases.1 Induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells.2 JNK抑制剂IX(312917-14-9)通过结合ATP结合域抑制JNK2和JNK3。 对JNK1, p38α和其他30种激酶的活性很低或没有活性 诱导人Jurkat T细胞前中期阻滞依赖的凋亡细胞死亡 。
References/Citations:
1) Angell et al. (2007), N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3; Med. Chem. Lett., 17 1296 2) Jang et al. (2014), Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells ; Biochem. Biophys. Res. Commun., 452 845
CAS:
312917-14-9
Catalog Number:
10-1528
Activity:
JNK inhibitor
Chemical Name:
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide
Alternate Names:
TCS JNK 5a
Molecular Weight:
332.42
Molecular Formula:
C20H16N2OS
Solubility:
Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT