SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA.1 Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model.2 SR-9009 suppresses atherosclerosis in a mouse model.3 Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues.4 Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.5 SR-9009(1379686-30-2)是一个激动剂的核受体Rev-ErbA.1 显著降低大鼠肺损伤模型中vili诱导的肺水肿、炎症细胞浸润和TNFα的产生 SR-9009在小鼠模型中抑制动脉粥样硬化 对癌细胞和致癌基因诱导的衰老细胞具有特异性致死作用,对正常细胞或组织的活力无影响 通过减少bmal1f/fNav1.8CreERT小鼠中BMAL1的表达来破坏骨关节炎相关的疼痛 。
References/Citations:
1) Solt et al. (2012) Regulation of circadian behavior and metabolism by synthetic REV-ERB agonists; Nature, 485 62 2) Li et al. (2014) A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury; Int.Immunopharmacol. 18 249 3) Sitaula et al. (2015) Suppression of atherosclerosis by synthetic REV-ERB agonist; Biochem. Biophys. Res. Commun.,460 566 4) Sulli et al. (2018) Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence; Nature, 553 351 5) Das et al. (2018) Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain; Gene 655 1
CAS:
1379686-30-2
Catalog Number:
10-1511
Activity:
RevErbα/β agonist
Chemical Name:
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Molecular Weight:
474.4
Molecular Formula:
C20H24CLN3O4S HCl
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT