AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively.1 Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. AdipoRon ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet.1 Attenuates PDGF-induced VSMC proliferation via inhibition of mTPR signaling in an AMPK independent manner.2 Active in vivo. AdipoRon(924416-43-3)是一种新型的强效选择性脂联素(AdipoR1和AdipoR2)受体激动剂,Kd分别为1.8和3.1 μM 与脂联素在肌肉和肝脏中的作用类似,如激活PPARα和AMPK信号通路。 它还能逆转高脂肪饮食小鼠的胰岛素抵抗和葡萄糖不耐受。 AdipoRon可以改善遗传性肥胖小鼠的糖尿病模型,延长高脂肪饮食的db/db小鼠缩短的寿命 通过不依赖于AMPK的方式抑制mTPR信号通路,减弱pdgf诱导的VSMC增殖 活跃的体内。
References/Citations:
1) Okada-Iwabu et al. (2013), A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature 503 493 2) Fairaq et al. (2017), AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia; Pharmacol. Res. 119 289
CAS:
924416-43-3
Catalog Number:
10-1483
Activity:
Adiponection agonist
Chemical Name:
2-(4-Benzylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Molecular Weight:
428.54
Molecular Formula:
C27H28N2O3 Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT