AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology.1 Cell permeable. AI-1(75483-04-4)是一种新型的抗氧化反应元件(ARE)激活剂,通过共价修饰Nrf2负调控因子Keap1 (Kelch-like ECH-associated protein 1)来激活Nrf2。 AI-1修饰Keap1的Cys151,破坏了Keap1作为Cul3-Keap1泛素连接酶复合物接头的能力,从而稳定并诱导Nrf2的转录激活。 人工智能-1是一个有用的药理学工具,以探讨Nrf2参与细胞生理学 细胞的渗透。
References/Citations:
1) Hur et al. (2010), A small-molecule inducer of the antioxidant response element; Chem. Biol., 17 537
CAS:
75483-04-4
Catalog Number:
10-1471
Activity:
Nrf2 activator
Chemical Name:
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
Molecular Weight:
265.70
Molecular Formula:
C13H12ClNO3 Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
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