NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2 Cell permeable.
References/Citations:
1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235 2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035
CAS:
157654-67-6
Catalog Number:
10-1385
Activity:
DUB inhibitor
Alternate Names:
F6
Chemical Name:
3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Molecular Weight:
339.86
Molecular Formula:
C21H21NO HCl
Solubility:
Soluble in DMSO (up to 8 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT