Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1 Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1 Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2 Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.
References/Citations:
1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060 2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732 3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551 4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764
CAS: 347174-05-4 Catalog Number: 10-1380 Activity: Ferroptosis inhibitor Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate Molecular Weight: 262.35 Molecular Formula: C15H22N2O2 Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml). Physical Properties: Tan solid Purity: 98% by TLC NMR (Conforms) Storage Temperature: RT Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Shipping Code: RT