产品分类
战略品牌
联系方式
公司新闻
壳聚糖低聚物，分子量 2 kDa-贝万塔生物，产品部分应用
发布时间：2023-12-03 21:07 | 点击次数：
产品编号：BC-10275
壳聚糖低聚物，分子量 2 kDa
英文名 Chitosan Oligomer, MW 2 kDa
CAS号 N/A
交货期：现货库存
价格：咨询客服
Chitosan oligosaccharide (COS) is an oligomer of β-(1 ➔ 4)-linked d-glucosamine. COS can be prepared from the deacetylation and hydrolysis of chitin, which is commonly found in the exoskeletons of arthropods and insects and the cell walls of fungi. COS is water soluble, non-cytotoxic, readily absorbed through the intestine and mainly excreted in the urine. Of particular importance, COS and its derivatives have been demonstrated to possess several biological activities including anti-inflammation, immunostimulation, anti-tumor, anti-obesity, anti-hypertension, anti-Alzheimer's disease, tissue regeneration promotion, drug and DNA delivery enhancement, anti-microbial, anti-oxidation and calcium-absorption enhancement. The mechanisms of actions of COS have been found to involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK). This review summarizes the current knowledge of the preparation methods, pharmacokinetic profiles, biological activities, potential therapeutic applications and safety profiles of COS and its derivatives. In addition, future research directions are discussed.
壳聚糖寡糖（COS）是β-（1➔44） -连接的d-葡糖胺。COS可以由甲壳质的脱乙酰和水解制备，甲壳质通常存在于节肢动物和昆虫的外骨骼以及真菌的细胞壁中。COS是水溶性的，无细胞毒性，易于通过肠道吸收，主要通过尿液排出。特别重要的是，COS及其衍生物已被证明具有多种生物活性，包括抗炎、免疫刺激、抗肿瘤、抗肥胖、抗高血压、抗阿尔茨海默病、促进组织再生、增强药物和DNA递送、抗微生物、抗氧化和增强钙吸收。已经发现COS的作用机制涉及几种重要途径的调节，包括抑制核因子κB（NF-κB）和促分裂原活化蛋白激酶（MAPK）以及激活AMP活化蛋白激酶。这个r