Firebird Biomolecular Sciences 创新核酸试剂产品简介

美国Firebird Biomolecular Sciences 为科研、合成生物学、临床诊断等研究机构单位提供创新试剂。

Firebird delivers reagent innovations to the research, synthetic biology, and clinical diagnostics communities.
Nucleic acid analogs for:
DNA sequencing
Diagnostics
SNP detection
Synthetic Biology

孚博生物优势进口Firebird Biomolecular Sciences的产品，提供合成可逆终止剂 dNTP-ONH2的订购和定制服务，价格优惠，货期2-4周，质量和售后有保障！

厂家有4种类型的合成可逆终止剂 dNTP-ONH2：
The ONH2 170 series: Ready to use, untagged
The ONH2 100 series: Oxime blocked, untagged
The ONH2 DT series: Diol linked tags
The ONH2 DS series: Disulfide linked tags

Reversible terminators: Oxime blocked, untagged
Reversible terminators with a free 3'-ONH2 are ready to use and do not require deprotection or further treatment before use.
Thymine，货号 TONH2-101，5 µmoles $900
Cytosine，货号 CONH2-102，5 µmoles $1050
Adenine，货号 AONH2-103，5 µmoles $1050
Guanine，货号 GONH2-104，5 µmoles $1050

Reversible terminators:  Oxime blocked, untagged
Reversible terminators are also available with the 3'-ONH2 protected as the acetoxime, which are more suitable for long term storage than our ready to use reversible terminators. For enzymatic incorporation, the oxime must be deprotected to the free 3' ONH 2 before use, which can be achieved in situ with buffered aqueous methoxylamine.
Thymine，货号：TONH2-101，5 µmoles $900
Cytosine，货号：CONH2-102，5 µmoles $1050
Adenine，货号：AONH2-103，5 µmoles $1050
Guanine，货号：GONH2-104，5 µmoles $1050

Reversible terminators: diol linked tags
Firebird offers reversible terminators with a 3'-ONH2 (protected as the acetoxime ) and a diol linker carrying a free amino group, to which a tag (fluorescent dye or other moiety) can be attached. The diol can be rapidly cleaved with dilute aqueous periodate.
Thymine，货号 TONH2-DT，1 µmole $1750
Cytosine，货号 CONH2-DT，1 µmole $1900
Adenine，货号 AONH2-DT，1 µmole $2200
Guanine，货号 GONH2-DT，1 µmole $2300

Reversible terminators: disulfide-linked tags
Firebird offers reversible terminators with a 3'-ONH2 (protected as the acetoxime) and a disulfide linker carrying a free amino group, to which a tag (fluorescent dye or other moiety) can be attached. The disulfide can be rapidly cleaved with phosphine or thiol reagents.
Thymine，货号 TONH2-ST，1 μmole $ 1750
Cytosine，货号 CONH2-ST，1 μmole $ 2000
Adenine，货号 AONH2-ST，1 μmole $ 2400
Guanine，货号 GONH2-ST，1 μmole $ 2500
For enzymatic incorporation, the oxime must be deprotected to the free 3'-ONH2 before use, which
can be achieved in situ with buffered aqueous methoxylamine.
 

AEGIS™ Artificially Expanded Genetic Information Systems
Firebird has created different heterocycles in order to implement additional hydrogen bonding patterns for the Z:P and S:B base pairs as shown below. These base pairs are “orthogonal” to C:G and A:T Benner, 2004; Hoshika et al., 2019 ; Sefah et al., 2014; Yang et al., 2006).

AEGIS: dZ and dP Phosphoramidites
dZ Phosphoramidite
Hydrogen bonding pattern: Z
Sugar: 2’-Deoxyribose
Heterocycle: Nitropyridine
Linear Formula C50 H 57 N 6 O 12 P
Mol Weight 964.99
Cat. No. dZ-PA-101
100 mg $ 720.00
1 gram $5760.00

dP Phosphoramidite
Hydrogen bonding pattern: P
Sugar: 2’-Deoxyribose
Heterocycle: Imidazotriazine
Linear Formula C49 H 65 N 8 O 7 P
Mol Weight 909.08
Cat. No. dP-PA-102
100 mg $ 850.00
1 gram $6800.00

Oligonucleotides are available that incorporate dZ and dP.
Ribonucleoside derivatives are also available.

AEGIS: dZ and dP Triphosphates
dZ Triphosphate
Hydrogen bonding pattern: Z
Sugar: 2’-deoxyribose
Heterocycle:Nitropyridine
Linear Formula C 10 H 16 N 3 O 15 P 3
Mol Weight 511.17
Cat. No. dZTP-101
1 µmole $ 400.00
5 µmoles $ 1600.00

dP Triphosphate
Hydrogen bonding pattern: P
Sugar: 2’-deoxyribose
Heterocycle: Imidazotriazine
Linear Formula C 10 H 16 N 5 O 13 P 3
Mol Weight 493.15
Cat. No. dPTP-201
1 µmole $ 420.00
5 µmoles $ 1680.00

Ribonucleoside triphosphates are also available. Please inquire.

AEGIS: dS and dB Phosphoramidites
dS Phosphoramidite
Hydrogen bonding pattern: S
Sugar: 2’-Deoxyribose
Heterocycle: Pseudo-C
Linear Formula C47 H 54 N 5 O 8 P
Mol Weight 847.93
Cat. No. dS-PA-104S
100 mg $ 720.00
1 gram $5760.00

dB Phosphoramidite
Hydrogen bonding pattern: B
Sugar: 2’-Deoxyribose
Heterocycle: Purine
Linear Formula C49 H 68 N 7 O 7 P
Mol Weight 898.08
Cat. No. dB-PA-103P
100 mg $ 600.00
1 gram $4800.00

Oligonucleotides are available that incorporate dS and dB.
Ribonucleoside derivatives are also available.

AEGIS: dS and dB Triphosphates
dS Triphosphate
Hydrogen bonding pattern: S
Sugar: 2’-deoxyribose
Heterocycle: Pseudo C
Linear Formula C 10 H 18 N 3 O 13 P 3
Mol Weight 481.18
Cat. No. dS*TP-401S
1 µmole $ 400.00
5 µmoles $ 1600.00

dB Triphosphate
Hydrogen bonding pattern: B
Sugar: 2’-deoxyribose
Heterocycle: Purine
Linear Formula C 10 H 16 N 5 O 13 P 3
Mol Weight 507.18
Cat. No. dBTP-301P
1 µmole $ 400.00
5 µmoles $ 1600.00

Ribonucleoside triphosphates are also available. Please inquire.

SAMRS™ Self Avoiding Molecular Recognition System
Nucleic acid amplification reactions suffer from the formation of off target amplification products. This problem increases with the number of primers in the reaction. It mainly occurs because of primer primer interactions. Thus, selectively removing hydrogen bonding units from the primer bases results in self avoiding DNA primers that can be added to enable and improve multiplexed PCR Hoshika et al., 2010)
SAMRS: Phosphoramidites
t* phosphoramidite
1 g $ 1050
10 g $ 8220
a* phosphoramidite
1 g $ 655
10 g $ 5340
c* phosphoramidite
1 g $ 394
10 g $3150
g* phosphoramidite
1 g $ 110
10 g $ 880
Oligonucleotides are available that incorporate the SAMRS bases.
SAMRS can be combined with AEGIS in oligos to get highly multiplexed and highly clean PCR, as well as isothermal amplification. Please inquire.