杭州湃肽生化科技有限公司提供药物肽/美容肽/定制肽/CRO多肽合作 电话:0571-89197072, 18668118770, QQ:1776791695 邮箱:linda@peptide-manufacturer.com Website:www.peptide-china.com www.peptide-manufacturer.com 1.杭州湃肽拥有一流的多肽药物合成、纯化、冻干以及质量研究的实验室和设备。 2.位于杭州海创园杭州湃肽和15000平方的绍兴多肽药物生产基地浙江湃肽,均参照欧美cGMP 标准兴建。 3.研发用药物肽有:普卡那肽,奥曲肽,亮丙瑞林,格拉替雷,比伐卢定,特立加压素,去氨加压素,艾塞那肽,卡贝缩宫素,特立帕肽,依替巴肽,阿托西班,利拉鲁肽,利那洛肽,地加瑞克,西曲瑞克,齐考诺肽,胰高血糖素,普兰林肽,阿拉瑞林,血管紧缩素,醋酸精氨酸加压素,依降钙素,恩夫韦肽,生长抑素,缩宫素,兰瑞肽,胸腺肽α1,替可克肽等。 4.提供化妆品用美容肽:九肽-1,肉豆蔻酰五肽-17(睫毛肽),棕榈酰三肽-1,棕榈酰四肽-7/3,棕榈酰五肽-5,SYN-AKE,乙酰基六胜肽-3/8,蓝铜胜肽,棕榈酰寡肽,棕榈酰五肽-3/4(美丽肽),乙酰四胜肽-5(眼丝氨肽),乙酰八胜肽,五肽-3,乙酰十胜肽-3,乙酰六肽-38等抗皱美白抗衰老活性胜肽。 5.定制肽合成有: (1)链长至200个氨基酸,毫克至克级,纯度可达99% (2)研究用多肽包括各种LHRH(GnRH)类似物、激动剂、拮抗剂、p淀粉样蛋白片段、酶底物、抑制剂及短肽 (3)研究级产品,从短肽到包含各种二硫键的复杂分子、改良肽、模拟题、肽缀合物及合成小蛋白(mg至kg级) 6.定制肽修饰有: (1)氨基化、糖基化、硫酸盐化、乙酰化、酰化、酰胺化 (2)荧光标记肽(FAM、FITC),生物素标记肽(BIOTIN) (3)环化作用:单个或多个二硫桥;头到尾;侧链(如内酰胺键、硫醚) (4)磷酸肽(Ser、Thr、Tyr),聚乙二醇修饰,AMC,醛化,CMK修饰 (5)与载体蛋白结合,如血蓝蛋白KLH,牛血清蛋白BSA,OVA (6)同位素标记(15N、13C) (7)复合抗原肽(MAP),多重氧化桥 (8)主干修饰为:羟亚乙基等排体;硫醚;逆转-反向肽;还原肽键 (9)与小分子结合(包括显像剂),与聚合物结合 (10)引进/合并:螯合基团;发色团和荧光团;荧光团/猝光剂对;D-旋光对应体;马来酰亚胺组、NHS酯类;α-和N-甲基氨基酸;非天然氨基酸 7.定制肽主要有:ACE Inhibitors(ACE抑制剂肽),Amylins(糊精肽),Adipokinetic Hormones(脂肪酸释放激素肽),Amyloids & Related Peptides(淀粉及关联肽),Adrenocorticotropic Hormones (ACTH)(促肾上腺皮质激素),Angiotensins(血管紧缩素),Adrenomedullins(肾脏髓质素肽),Anti-Inflammatory Peptides(消炎肽),Agouti-Related Proteins(刺豚鼠相关肽),Antibiotic Peptides(抗生素肽),Allatostatins(咽侧体抑制素),Antimicrobial Peptides(抗菌肽),Apelin Peptides(爱帕琳肽),Atrial Natriuretic Peptides(心房利钠肽),Apoptosis & Related Peptides(细胞凋亡及相关肽),Antioxidant Peptides(抗氧化肽),Bag Cell Peptides(袋细胞肽),Bone Gla Proteins(骨钙蛋白质),Big Endothelin & Analogs(大内皮素及类似物),Bradykinins(血管舒缓激肽),Bombesins(铃蟾肽),Brain Natriuretic Peptides (BNP)(脑钠尿肽),Corticotropin-releasing hormone(促肾上腺皮质素释放素),C-Peptides,Calpain Inhibitors(钙蛋白酶抑制剂),C-Type Natriuretic Peptides(C型利钠肽),CARTS,Calcitonin & Calcitonin Gene Related Peptides(降血钙素及其基因相关肽),Casomorphins(酪啡肽),Cathepsins and Related Products(组织蛋白酶及相关肽), Conotoxins & Other Toxins,Chloromethylketones,Corticotropin Releasing Factors(保皮质释放素),Cholecystokinins (CCK)(胆囊收缩素),Cortistatins,Defensins(防御素),Dynorphins(强啡肽),Endomorphins(内吗啡肽),Endothelin-2, Endothelin-3 & Analogs(内皮素-2,内皮素-3及类似物),Endorphin(内啡肽),Endothelins & Related Peptides(内批素及相关肽),Endostatin(内皮抑素),Enkephalins,Endothelin-1 & Analogs(内皮素-1及类似物),Exendins(促胰岛素分泌肽),Fibronectin and Extra Cellular Matrix Related Peptide(纤维结合素及细胞外基质相关肽),FMRF & Analogs, Galanins(促生长激素神经肽),Glucagons and Glucagon-Like Peptides(胰高血糖素及其类似物),Gastric Inhibitory Peptides(抑胃肽),GnRH Associated Peptides(生长激素相关肽),Guanylins,Growth Factor Fragments(生长因子片段肽),Gastrins(胃泌素),Growth Hormone & Growth Hormone Releasing Factors peptide(生长激素及其释放因子),Ghrelins,GTP-Binding Protein Fragments(GTP限制蛋白质片段),Insect-Neuropeptides(昆虫神经肽),Insulin & related peptides(胰岛素及相关肽),Laminin Peptides(层粘连蛋白肽),Leptin Fragment Peptides(瘦素片段肽),LH-RH & Analogs,Mast Cell Degranulating Peptides(肥大细胞脱颗粒肽),Miscellaneous Peptides,Melanin Concentrating Hormone (MCH)(黑色素浓集激素),Myelin Oligodendrocyte Glycoprotein (MOG) Peptide,Melanocyte Stimulating Hormones (MSH)(促黑激素),MMP Substrates,Melanoma peptides(黑色素瘤肽),Motilins,Neurokinins(神经激肽),Neuroendocrine Regulatory Peptides,Neuromedins(神经介素),Neuropeptide Y & Analogs,Neuropeptide Y & Analogs,Neurotensins(神经降压素),Neuropeptide W-23 and Analog(神经肽W-23和类似物),Opioid Related Peptides,Orexins(神经肽),Oxytocins(缩宫素 、催产素),Pancreastatin & Related Peptides(胰抑制素及相关肽),Petidase Substrates,Pancreatic Polypeptides(胰多肽),Pituitary Adenylate Cyclase Activating Peptides,Parathyroid Hormone & Analogs (PTH)(甲状旁腺(激)素及类似物),Prolactin Releasing Peptide(泌乳刺激素释放肽),Peptides YY,Protein Kinase and Related Peptides(蛋白激酶及相关肽),Protease Inhibitor,Phalloidins,Renin Substrates & Inhibitors(血管紧张肽原酶底物和抑制剂),Secretins(分泌素),Substance P & Related Peptides,Signal Transduction Reagents(信号转导肽),Sarafotoxins,Somatostatin & Analogs(生长抑素及类似物),Substrate & Enzyme Inhibitors(底物和酶抑制剂),Stresscopin Related Peptides,TAT Proteins,Thrombospondin-I (TS-I) Cell Binding Domain,Thrombin related peptides (凝血酶相关肽),Thymopoietin & Thymosin Peptides(促胸腺生成素及胸腺素肽),Thrombospondin(血小板反应素),Thyrotropin-Releasing Hormones (TRH)(促甲状腺激素释放激素),Urocortins(尿皮素),Urotensins,Vasoactive Intestinal Peptides (VIP)(血管活性肠肽),Vasopressins(抗利尿激素),Virus Related Peptides(病毒相关肽) |