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PINK1-(D8G3)-Rabbit-mAb

  • 价  格: 询价
  • 抗体英文名: PINK1 (D8G3) Rabbit mAb
  • 是否单克隆: false
  • 保存条件: -20°c
  • 品  牌: CST
  • 试用规格: Microsize T包装(20ul)
  • 级  别: 详见MSDS文件
  • 产  地: USA
  • 保  质  期: 详见说明书
  • 供  应  商: CST
  • 抗  原: synthetic peptide corresponding to residues surrounding Pro140 of human PINK1 protein
  • 适应物种: H
  • 应用范围: W, IP
  • 货  号: 6946
在线询问 已有 15 人申请试用
美国CST中国公司(丁香通商铺)
商家诚信度:
成立时间:2008
入驻丁香通年限:6年
商家等级:金牌客户
产品信息完整度:47.0%
联系人:陈小姐

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电话:021-58356288

邮件:info@cst-c.com.cn

传真:021-58356116

地址:上海市浦东南路1101号远东大厦514

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* 试用品 PINK1 (D8G3) Rabbit mAb (15 人申请)
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试用说明

试用申请时间: 2019年05月22日— 2019年06月22日 1. 运费:顺丰到付(约50-100元不等)
2. 发货时间:6月24~28日审核,7月1~5日发货,电话确认申请成功后,请耐心等待2-3周时间收货。
3. 申请要求:务必于3-6个月提交试用报告。
4. 限制条件:仅适合终端客户,一个PI课题组仅限申领一支。
5.备注:请认真填写申请理由。

产品详情

规格: 产品价格: 询价

pathway more info application references datasheet PDF MSDS PDF protocols

 

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

 

Applications Reactivity Sensitivity MW (kDa) Isotype
W IP H Endogenous 60, 50 Rabbit IgG
Protocols
Specificity / Sensitivity

PINK1 (D8G3) Rabbit mAb recognizes endogenous levels of total PINK1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro140 of human PINK1 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a cDNA construct expressing full-length human PINK1 (hPINK1, +) using PINK1 (D8G3) Rabbit mAb.

Western Blotting

Western Blotting

Western blot analysis of extracts from HeLa cells, untreated (-) or treated with CCCP (10 μM, 24 hr; +), using PINK1 (D8G3) Rabbit mAb.

Background

PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria (1-3). PINK1 phosphorylates Parkin and promotes its translocation to mitochondria (2). Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction (1,3).

 

  1. Liu, W. et al. (2009) PLoS One 4, e4597.
  2. Kim, Y. et al. (2008) Biochem Biophys Res Commun 377, 975-80.
  3. Petit, A. et al. (2005) J Biol Chem 280, 34025-32.
Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

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For Research Use Only. Not For Use In Diagnostic Procedures.

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