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Arginase-1 (D4E3M™) XP® Rabbit mAb

  • 价  格: 询价
  • 品  牌: Cell Signaling Technology
  • 货  号: 93668
  • 抗体英文名: Arginase-1 (D4E3M™) XP® Rabbit mAb
  • 试用规格: Microsize 20ul
  • 靶  点: Arginase-1
  • 应用范围: WB、IHC-P、IHC-F、IF
  • 宿  主: Rabbit
  • 适应物种: Human, Mouse, Rat
  • 克  隆  性: false
  • 保存条件: -20C
  • 产  地: 美国
在线询问 已有 17 人申请试用
美国CST中国分公司(丁香通商铺)
商家诚信度:
成立时间:2008
入驻丁香通年限:5年
商家等级:金牌客户
产品信息完整度:50.0%
联系人:陈小姐

若您通过QQ未能联系到商家,您可以给商家发送站内信,与其取得联系。

电话:021-58356288

邮件:info@cst-c.com.cn

传真:021-58356116

地址:上海市浦东南路1101号远东大厦514

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试用说明

试用申请时间: 2018年01月19日— 2018年02月19日 1. 运费:自理,货到付款。
2. 发货时间:2018年3月1日
3. 申请要求:每个PI课题组,限申请一支;供未试用过CST产品的客户试用。
4. 其他说明:试用者有义务提交试用报告,同意者方可申请试用。

产品详情

规格: 产品价格: 询价

了解产品详情,见CST中国官网:https://www.cst-c.com.cn/products/primary-antibodies/arginase-1-d4e3m-xp-rabbit-mab/93668。


Arginase-1 (D4E3M™) XP® Rabbit mAb recognizes endogenous levels of total arginase-1 protein. This antibody does not cross-react with arginase-2.

Species Reactivity: Human, Mouse, Rat
 

Application Dilutions
Western Blotting 1:1000
IHC-Leica® Bond™ 1:400
Immunohistochemistry (Paraffin) 1:100
Immunofluorescence (Frozen) 1:50
Immunofluorescence (Immunocytochemistry) 1:50

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Background:

L-arginine plays a critical role in regulating the immune system (1-3). In inflammation, cancer and certain other pathological conditions, myeloid cell differentiation is inhibited leading to a heterogeneous population of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs). MDSCs are recruited to sites of cancer-associated inflammation and express high levels of arginase-1 (4). Arginase-1 catalyzes the final step of the urea cycle converting L-arginine to L-ornithine and urea (5). Thus MDSCs increase the catabolism of L-arginine resulting in L-arginine depletion in the inflammatory microenvironment of cancer (4, 6). The reduced availability of L-arginine suppresses T-cell proliferation and function and thus contributes to tumor progression (4, 6). Arginase-1 is of great interest to researchers looking for a therapeutic target to inhibit the function of MDSCs in the context of cancer immunotherapy (7). In addition, research studies have demonstrated that Arginase-1 distinguishes primary hepatocellular carcinoma (HCC) from metastatic tumors in the liver, indicating its value as a potential biomarker in the diagnosis of HCC (8, 9).

  1. Albina, J.E. et al. (1989) J Exp Med 169, 1021-9.
  2. Mills, C.D. (2001) Crit Rev Immunol 21, 399-425.
  3. Rodriguez, P.C. et al. (2004) Cancer Res 64, 5839-49.
  4. Gabrilovich, D.I. and Nagaraj, S. (2009) Nat Rev Immunol 9, 162-74.
  5. Wu, G. and Morris, S.M. (1998) Biochem J 336 ( Pt 1), 1-17.
  6. Raber, P. et al. (2012) Immunol Invest 41, 614-34.
  7. Wesolowski, R. et al. (2013) J Immunother Cancer 1, 10.
  8. Sang, W. et al. (2015) Tumour Biol 36, 3881-6.
  9. Geramizadeh, B. and Seirfar, N. (2015) Hepat Mon 15, e30336.
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