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兔Bcl-Xl 多克隆抗体
- 参考价格： 询价
- 品 牌： novus
- 货 号： NB110-83982V
- 靶 点： Bcl-Xl 查看全部Bcl-Xl 抗体
- 适应物种： 人,犬,猫,绵羊
- 应用范围： 免疫印迹,免疫细胞化学/免疫荧光
- 克 隆 性： Polyclonal
- 宿 主： Rabbit
产品概览
| 背景： | BCL2L1 (BCL2-like 1) is a member of BCL-2 protein family and proteins encoded by this gene are located at the outer mitochondrial membrane, where they have been shown to control outer mitochondrial membrane channel (VDAC) opening. VDAC has the ability to regulate mitochondrial membrane potential which is critical to regulation of ROS production as well as release of cytochrome c by mitochondria, both of which are the potent inducers of cellular apoptosis. BCL2L1 also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. There are two alternatively spliced transcript variants, which encode distinct isoforms, and the longer isoform Bcl-X(L) acts as an apoptotic inhibitor whereas the shorter form Bcl-X(L) acts as an apoptotic activator. Bcl-X(S) is expressed at high levels in cells undergoing high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| 免疫原： | Synthetic peptide made to an N-terminal portion of human BCL2L1 (within residues 30-70). [Swiss-Prot# Q07817] |
| 产品保证说明： | All of our products are backed by our 100% guarantee to work for stated and predicted species and applications. |
| 产品别名： | BCL-XL/SBcl2-L-1BCLXSbcl2-L-1BCLXLbcl-2-like protein 1Apoptosis regulator Bcl-Xbcl-xSbcl-xLBCLXBCL2LBcl-XDKFZp781P2092BCL2-like 1 |
产品特性
| 纯度： | Immunogen affinity purified |
| 预测适应物种： | Porcine (93%). Backed by our 100% guarantee. |
靶点信息
| uniprot： |
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| 基因： | BCL2L1 |
| 基因标志： | BCL2L1 |
| 基因相关产品： | BCL2,BAX,CASP3,CASPASE 3,CYCS,TNF,TP53,BAK1,AKT1,FAS,CASP9,MCL1,BID,CASP8,CDKN1A,NFKB1,PARP1,XIAP,BCL2L11,CASPASE 9 |
| 胞内定位： | Mitochondrion membrane; Single-pass membrane protein (By similarity). Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=Mitochondrial membranes and perinuclear envelope (By similarity). |
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| uniprot： |
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应用与保存
| 免疫原： | Synthetic peptide made to an N-terminal portion of human BCL2L1 (within residues 30-70). [Swiss-Prot# Q07817] |
| 防腐剂： | No Preservative |
| 应用说明： | This BCL2L1 antibody is useful for Western blot, where a band is seen ~26 kDa. This antibody is not useful for ICC/IF. |
| 稀释浓度： |
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其他
| 保存条件： | Store at 4C in the dark. |
| 标记物： | DyLight 405 (A=400, E=420) |
| 分子量： | 26 kDa |
| 浓度： | 1 mg/ml |
| 温馨提示： | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies areguaranteedfor 1 year from date of receipt. |
| 特异性： | There are three known isoforms of Bcl-X; Bcl-X(S), Bcl-X(beta), and Bcl-X(L). The immunogen used to create this has 100% identity to all three isoforms. |
| 缓冲液： | 50mM sodium borate |
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