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兔APE1 多克隆抗体
- 参考价格： 询价
- 品 牌： novus
- 货 号： NB100-101H
- 靶 点： APE1 查看全部APE1 抗体
- 适应物种： 人,小鼠,大鼠,灵长类动物,兔
- 应用范围： 免疫印迹,免疫细胞化学,免疫沉淀
- 克 隆 性： Polyclonal
- 宿 主： Rabbit
产品概览
| 背景： | The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control. |
| 免疫原： | Affinity purified human APE1 [UniProt# P27695] |
| 产品保证说明： | All of our products are backed by our 100% guarantee to work for stated and predicted species and applications. |
| 产品别名： | APEAPEX nucleaseAP endonuclease 1EC 3.1APE1redox factor 1Redox factor-1protein REF-1Apurinic-apyrimidinic endonuclease 1multifunctional DNA repair enzymeREF-1DNA-(apurinic or apyrimidinic site) lyaseAPE-1APEX deoxyribonuclease (apurinic or apyrimidinic)REF1 apurinic/apyrimidinic exonucleaseHAP1apurinic/apyrimidinic (abasic) endonucleaseAPXAP lyaseAPENAP endonuclease class IAPEAPEX nuclease (multifunctional DNA repair enzyme)EC 4.2.99.18APEX nuclease (multifunctional DNA repair enzyme) 1 |
产品特性
| 纯度： | Immunogen affinity purified |
靶点信息
| uniprot： |
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| 基因： | APEX1 |
| 基因标志： | APEX1 |
| 基因相关产品： | AP,REF-1,CAT,OGG1,GSR,JUN,SOD1,CRAT,GLYAT,FOS,POLB,XRCC1,APURINIC/APYRIMIDINIC ENDONUCLEASE 1,NR3C1,TP53,LIG4,FOSB,JUND,JUNB,UNG |
| 胞内定位： | In immunohistochemical experiments punctate nuclear staining is seen in most cell types. However, in hepatocytes, large neurons and granule cells, cytoplasmic staining is observed. |
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| uniprot： |
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应用与保存
| 免疫原： | Affinity purified human APE1 [UniProt# P27695] |
| 防腐剂： | No Preservative |
| 应用说明： | This APE1 antibody is useful for Blocking/Neutralizing, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot. In WB this antibody detects a single band at 37 kDa. In IHC it can be competitively inhibited from recognizing the APE1 antigen in tissues using APE1 protein. This antibody can be used on frozen sections, fixed-paraffin sections and cytospin preps. NB100-101 can also be used following the apoptosis (TUNEL) procedure with the Boehringer-Mannheim TUNEL assay kit. Antibody staining should be performed AFTER the TUNEL assay. NB100-101 can inhibit the repair activity of APE1 protein. |
| 稀释浓度： |
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其他
| 保存条件： | Store at 4C in the dark. |
| 标记物： | HRP |
| 分子量： | 37 kDa |
| 抑制剂： | |
| 浓度： | 0.5 mg/ml |
| 温馨提示： | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies areguaranteedfor 1 year from date of receipt. |
| 缓冲液： | PBS |
| 读出系统： |
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