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兔Histone H3 多克隆抗体
- 参考价格： 询价
- 品 牌： novus
- 货 号： NB21-1072
- 靶 点： Histone H3 查看全部Histone H3 抗体
- 适应物种： 人,小鼠,秀丽隐杆线虫
- 应用范围： 免疫印迹,染色质免疫沉淀技术,斑点印迹,免疫细胞化学/免疫荧光
- 克 隆 性： Polyclonal
- 宿 主： Rabbit
产品概览
| 背景： | Dimethylated histone H3 at lysine 9 is associated with several inflammatory diseases. Usually, the histone modification is implicated through a one-off association with critical disease related genes. For example, in Alzheimers disesase, amyloid beta-peptide accumulation is caused by insufficient neprilysin, which is in turn caused by increased concentrations of H3K9me2 in the neprilysin promoter following exposure to hypoxia. In osteoarthritis, increased H3K9me2 at the NFAT1 promoter represses the expression of NFAT, resulting in overexpression of proinflammatory cytokines. PHF2 and ARID5B are important in regulating the methylation of H3 at K9, and thus chromatin reorganization and gene transcription. |
| 免疫原： | Synthetic dimethylated peptide surrounding Lysine 9 of human Histone H3.2 [Swiss Prot Q71DI3]. |
| 产品保证说明： | All of our products are backed by our 100% guarantee to work for stated and predicted species and applications. |
| 产品别名： | H3.3BMGC87782histone H3.3H3.3AH3F3H3F3BMGC87783H3 histone, family 3A |
产品特性
| 纯度： | Immunogen affinity purified |
| 预测适应物种： | Rat (100%), Chicken (100%), Drosophila (100%), Plant (100%), Xenopus (100%). Backed by our 100% guarantee. |
| 阳性对照： | 6 Positive Controls |
靶点信息
| uniprot： | |
| 基因： | HIST2H3C |
| 基因标志： | HIST2H3C |
| 基因相关产品： | HIST1H3E,HIST1H3C,HIST2H4A,HIST1H4F,HISTONE H3,HIST2H2BE,HIST2H2AA3,HIST1H2AE,HRH4,CCDC6,HIST2H2AC,HIST1H4I,HIST4H4,HIST1H2AK,HIST1H3A,HIST1H3D,HIST1H2AM,HIST1H4D,HIST1H4J,HIST1H4K |
| 胞内定位： | Nucleus. Chromosome. |
| entrez： | |
| uniprot： |
应用与保存
| 免疫原： | Synthetic dimethylated peptide surrounding Lysine 9 of human Histone H3.2 [Swiss Prot Q71DI3]. |
| 防腐剂： | 0.05% Sodium Azide |
| 应用说明： | This Histone H3 K9me2 antibody is useful for ChIP, ICC/IF, Dot Blot, and Western Blot where a band is seen ~15 kDa in HeLa histone preps and C. elegans embryo lysate. |
| 稀释浓度： |
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其他
| 对照肽： | Histone H3 Peptide (NB21-1072PEP) |
| 保存条件： | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| 备注： | 0.05 mg of HeLa histone preps will be included in the shipment along with the primary antibody as an appropriate positive control. For SDS-PAGE with the positive control we recommend loading 0.01 mg per lane.Epi-Plus antibody production in collaboration with Rockland Immunochemicals Inc. |
| 标记： | Nuclear Marker |
| 浓度： | 0.6 mg/ml |
| 温馨提示： | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies areguaranteedfor 1 year from date of receipt. |
| 缓冲液： | PBS, 30% glycerol |
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