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trap 单克隆抗体

  • 参考价格: ¥3190.0
  • 品  牌:  abgent
  • 货  号:  AJ1790a
  • 适应物种:  人,小鼠
  • 应用范围:  免疫印迹,流式细胞技术
  • 克 隆 性:  单克隆
  • 主要序列号:  P29965
  • 克 隆 名:  EP462E
  • 详细信息
  • 图片

详细信息

产品概览

背景: TRAP cleavage (CD40 Ligand), a 35 kDa ligand, is transiently expressed on the surface of T-cells and binds to CD40, which is expressed on the surface of B-cells. This binding event leads to the differentiation, proliferation, and isotype switching of the B-cells. The physiological importance of CD40L has been demonstrated by the fact that expression of defective CD40L protein causes an immunodeficiency state characterized by high IgM and low IgG serum levels, indicating faulty T-cell dependent B-cell activation (1). Abnormalities in the CD40L gene are associated with an X-linked immunodeficiency in humans [hyper-IgM (immunoglobulin M) syndrome]. This disease is characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes (2). This CD40L is expressed on activated T cells, mostly CD4+ but also some CD8+ as well as basophils/mast cells. Cross-linking of CD40 with immobilized anti-CD40 or cells expressing CD40L induces B cells to proliferate strongly, and addition of IL-4 or IL-13 allows the generation of factor-dependent long-term normal human B cell lines and the secretion of IgE following isotype switching (3).REFERENCES1. Singh J, et al. Protein Sci. 7(5):1124-35, 1998.2. Allen RC, et al. Science 259(5097):990-3, 1993.3. Banchereau J, et al. Annu Rev Immunol. 12:881-922, 1994
其他名字: CD40LG, CD40L, TNFSF5, TRAP, CD40 ligand, soluble form, T-cell antigen Gp39

靶点信息

基因id: 959
蛋白名: CD40LG
胞内定位: Cell membrane; Single-pass type II membrane protein
同义词: CD40L, TNFSF5, TRAP

应用与保存

稀释浓度: WB~~1:5000FC~~1:40
注意事项: TRAP (CD40) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

其他

参考文献: 1. Singh J, et al. Protein Sci. 7(5):1124-35, 1998.2. Allen RC, et al. Science 259(5097):990-3, 1993.3. Banchereau J, et al. Annu Rev Immunol. 12:881-922, 1994
保存条件: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
标记物: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
分子量: 29274 Da
功能: Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
规格: 100µl 价格: ¥3190.00

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