NF-κB NF-κB是一种控制DNA转录的蛋白质复合物。NF-κB几乎存在于所有动物细胞类型中,并参与机体的炎症反应、免疫应答,能调节细胞凋亡、应激反应。 NF-κB网络由五个家族成员蛋白单体(p65 / RelA,RelB,cRel,p50和p52)组成,它们形成同源二聚体或异二聚体,其差异结合DNA并受两种途径调节:经典的NF-κB必需调节剂(NEMO)依赖性途径和非经典的NEMO非依赖性途径。NF-κB通路的过度激活,与人类许多疾病相关,如哮喘、类风湿性关节炎、炎症性肠病、心脏与脑部疾病的炎症等。此外,改变的NF-κB调节可能涉及其他疾病,如动脉粥样硬化和阿尔茨海默病和各种各样的人类癌症。 NF-κB通路转导过程 NF-κB经典信号通路中,通过IκB蛋白降解释放NF-κB二聚体。细胞受到胞外刺激后,信号因子与细胞膜上的受体结合,激活IκB激酶(IKK)。IκB磷酸化后进一步泛素化,进而释放NF-κB二聚体。NF-κB二聚体经翻译后修饰(磷酸化、乙酰化、糖基化等)激活,并转运入胞核,在核内单独或联合其他转录因子,促进基因的表达。 NF-κB非经典信号通路中,则通过p100到p52的加工处理来激活信号通路。信号转导通过受体子集(LTβR、CD40和BR3等),激活激酶NIK,进而激活IKKα复合体,IKKα复合体再磷酸化NF-κB2 p100(C端残基)。磷酸化后的NF-κB2 p100将自身泛素化,再经蛋白酶加工为NF-κB2 p52。此时,在胞浆中失活的NF-κB2 p100/RelB已激活为NF-κB p52/RelB 复合体,转运入胞核,诱导目的基因的表达。 NF-κB信号通路图产品列表按靶点分类: *HDAC
项目号 |
产品名称 |
规格 |
CAS |
包装 |
细胞 |
靶点 |
IC50 |
Ki |
V125336 |
Vorinostat |
≥99.0% |
149647-78-9 |
100mg,500mg,1g,5g |
无细胞 |
HDAC |
~10 nM |
|
E125068 |
Entinostat (MS-275) |
≥98% |
209783-80-2 |
10mg,50mg,100mg,250mg |
无细胞 |
HDAC1 |
0.51 μM |
|
HDAC3 |
1.7 μM |
|
P125167 |
Panobinostat (LBH589) |
≥98% |
404950-80-7 |
10mg,50mg |
无细胞 |
HDAC |
5 nM |
|
T129665 |
Trichostatin A |
≥98% |
58880-19-6 |
5mg,10mg,50mg |
无细胞 |
HDAC |
~1.8 nM |
|
M126151 |
Mocetinostat (MGCD0103) |
≥98% |
726169-73-9 |
5mg,25mg,50mg |
无细胞 |
HDAC1 |
0.15 μM |
|
S135494 |
软木肟酸 |
95% |
38937-66-5 |
1g,5g |
|
HDAC1 |
0.25 μM |
|
HDAC3 |
0.3 μM |
|
B126780 |
Belinostat (PXD101) |
≥98% |
414864-00-9 |
10mg,50mg,250mg |
无细胞 |
HDAC |
27 nM |
|
R125265 |
Romidepsin (FK228, Depsipeptide) |
≥99% |
128517-07-7 |
1mg,5mg |
无细胞 |
HDAC1 |
36 nM |
|
HDAC3 |
47 nM |
|
M127417 |
MC1568 |
≥97%(HPLC) |
852475-26-4 |
10mg,25mg |
无细胞 |
HD1-A |
100 nM |
|
T129677 |
Tubastatin A HCl |
≥98% |
1310693-92-5 |
10mg,50mg,250mg |
无细胞 |
HDAC6 |
15 nM |
|
G129672 |
Givinostat (ITF2357) |
≥95% |
732302-99-7 |
5mg,10mg,50mg |
无细胞 |
HD2 |
10 nM |
|
HD1B |
7.5 nM |
|
HD1A |
16 nM |
|
C127191 |
CUDC-101 |
≥98% |
1012054-59-9 |
10mg,25mg,50mg,100mg,250mg |
|
HDAC |
4.4 nM |
|
EGFR |
2.4 nM |
|
HER2 |
15.7 nM |
|
P127910 |
Pracinostat (SB939) |
≥98% |
929016-96-6 |
5mg,10mg,50mg |
|
pan-HDAC |
40-140 nM |
|
P126351 |
PCI-34051 |
≥98% |
950762-95-5 |
10mg,50mg |
无细胞 |
HDAC8 |
10 nM |
|
D127578 |
Droxinostat |
≥96% |
99873-43-5 |
5mg,10mg,25mg |
|
HDACs 6 |
2.47μM |
|
HDACs 8 |
1.46 μM |
|
P126975 |
PCI-24781 (Abexinostat) |
≥97% |
783355-60-2 |
5mg,10mg,50mg |
|
HDAC1 |
|
7 nM |
R129686 |
RGFP966 |
≥98% |
1396841-57-8 |
5mg,25mg,100mg |
无细胞 |
HDAC3 |
0.08μM |
|
A127913 |
AR-42 |
≥99% |
935881-37-1 |
2mg,5mg,10mg,50mg |
HDAC |
30 nM |
|
A124886 |
Rocilinostat (ACY-1215) |
≥98% |
1316214-52-4 |
5mg,10mg,50mg |
无细胞 |
HDAC6 |
5 nM |
|
C126432 |
CI-994 |
≥98% |
112522-64-2 |
10mg,50mg,250mg |
|
HDAC 1 |
0.9 μM |
|
HDAC 2 |
0.9 μM |
|
HDAC 3 |
1.2 μM |
|
HDAC 8 |
>20 μM |
|
C126527 |
CUDC-907 |
≥99% |
1339928-25-4 |
5mg,10mg,50mg |
|
PI3Kα |
19 nM |
|
HDAC1 |
1.7 nM |
|
HDAC2 |
5 nM |
|
HDAC1/2/3/10 |
1.8 nM |
|
HDAC1/2/3/10 |
2.8 nM |
|
C140600 |
姜黄素 |
≥65% |
458-37-7 |
5g,25g,100g |
|
p300 histone acetylatransferase |
~25 μM |
|
Histone deacetylase |
|
C110685 |
姜黄素 |
分析标准品 |
458-37-7 |
20mg |
|
p300 histone acetylatransferase |
Histone deacetylase |
|
M125894 |
M344 |
≥97% |
251456-60-7 |
5mg,25mg,100mg |
|
HDAC |
100 nM |
|
R127721 |
RG2833 |
≥98% |
1215493-56-3 |
5mg,10mg,25mg,50mg,100mg |
|
HDAC1 |
60 nM |
|
HDAC3 |
50 nM |
|
S125104 |
Scriptaid |
≥99% |
287383-59-9 |
1mg,5mg |
|
HDAC |
|
|
T125086 |
Tasquinimod |
≥99% |
254964-60-8 |
5mg,10mg,50mg |
|
|
|
|
S161350 |
斯普利特麻一辛 |
>98.0%(GC) |
5690-03-9 |
200mg,1g |
|
HDAC4 |
|
|
P115736 |
小白菊内酯 |
≥98% |
20554-84-1 |
20mg |
|
HDAC1 |
|
|
*NF-κB
项目号 |
产品名称 |
规格 |
CAS |
包装 |
细胞 |
靶点 |
IC50 |
Q125550 |
QNZ (EVP4593) |
≥98% |
545380-34-5 |
5mg,25mg,100mg |
Jurkat T |
NF-κB |
11 nM |
TNF-α |
7 nM |
C140600 |
姜黄素 |
≥65% |
458-37-7 |
5g,25g,100g |
|
p300 histone acetylatransferase |
~25 μM |
Histone deacetylase |
C110685 |
姜黄素 |
分析标准品 |
458-37-7 |
20mg |
|
p300 histone acetylatransferase |
~25 μM |
Histone deacetylase |
S115316 |
对氨基水杨酸钠 |
98% |
6018-19-5 |
25g,50g,100g,250g,1kg |
|
NF-κB |
|
M134534 |
JSH-23 |
≥98% (HPLC) |
749886-87-1 |
25mg,100mg |
RAW 264.7细胞系 |
NF-κB |
7.1 μM |
C102139 |
咖啡酸苯乙酯 |
97% |
104594-70-9 |
25mg,250mg,1g,5g,25g,100g |
|
NF-κB |
|
S104176 |
水杨酸钠 |
AR,≥99.5% (NT) |
54-21-7 |
250g,500g,1kg,5kg |
|
NF-κB |
|
S104177 |
水杨酸钠 |
CP,99.5% |
54-21-7 |
100g,250g,500g,1kg |
|
NF-κB |
|
S104179 |
水杨酸钠 |
USP级 |
54-21-7 |
250g,1kg |
|
NF-κB |
|
A101649 |
穿心莲内酯 |
98% |
5508-58-7 |
100mg,500mg,1g,5g |
|
|
|
A101650 |
穿心莲内酯 |
分析标准品 |
5508-58-7 |
20mg |
|
|
|
E140884 |
吴茱萸碱 |
98% |
518-17-2 |
1g,5g,25g |
|
IkB kinase |
|
E101966 |
吴茱萸碱 |
分析标准品,≥99% |
518-17-2 |
20mg |
|
IkB kinase |
|
I105220 |
3-吲哚甲醇 |
96% |
700-06-1 |
1g,5g,25g,100g,500g |
|
NF-κB |
|
IκBα |
|
M111377 |
厚朴酚 |
分析标准品,>98% |
528-43-8 |
20mg |
|
TNFα |
|
M111378 |
厚朴酚 |
≥98%(HPLC) |
528-43-8 |
50mg,250mg,1g,5g |
|
TNFα |
|
P115736 |
小白菊内酯 |
≥98% |
20554-84-1 |
20mg |
|
HDAC1 |
|
T107399 |
雷公藤甲素 |
分析标准品,≥98% |
38748-32-2 |
10mg,20mg |
|
NF-κB |
|
T107400 |
雷公藤甲素 |
98% |
38748-32-2 |
50mg |
|
NF-κB |
|
D104017 |
马来酸二乙酯 |
96% |
141-05-9 |
25ml,100ml,500ml,2.5L |
|
NF-κB |
|
*IκB/IKK
项目号 |
产品名称 |
规格 |
CAS |
包装 |
细胞 |
靶点 |
IC50 |
B126947 |
BX-795 |
≥97% |
702675-74-9 |
10mg,50mg,100mg |
无细胞 |
PDK1 |
6 nM |
B129693 |
BAY 11-7082 |
≥98% |
19542-67-7 |
50mg,250mg,1g |
肿瘤细胞 |
IκBα |
10 μM |
I129698 |
IKK-16 (IKK Inhibitor VII) |
≥99% |
873225-46-8 |
10mg,50mg |
无细胞 |
IKK-2 |
40 nM |
IKK complex |
70 nM |
IKK-1 |
200 nM |
T126861 |
TPCA-1 |
≥98% |
507475-17-4 |
5mg,25mg,100mg |
无细胞 |
IKK-2 |
17.9 nM |
I129696 |
IMD 0354 |
≥99% |
978-62-1 |
5mg,10mg,50mg |
|
IKKβ |
|
W124219 |
蟛蜞菊内酯 |
≥98%(HPLC) |
524-12-9 |
1mg,5mg,25mg |
|
IKK |
|
B129704 |
Bardoxolone Methyl |
≥98% |
218600-53-4 |
25mg,100mg |
|
IKK |
|
S126740 |
SC-514 |
≥98% |
354812-17-2 |
10mg,50mg |
|
IKK-2 |
3-12 μM |
A129982 |
5-氨基水杨酸 |
≥99% |
89-57-6 |
5g,25g,100g,500g |
|
|
|
B168290 |
Bay 11-7085 |
98% (HPLC) |
196309-76-9 |
10mg |
|
IκBα |
10 μM |
M126461 |
MRT67307 |
≥98% |
1190378-57-4 |
10mg,50mg |
|
IKKϵ |
160 nM |
TBK1 |
19 nM |
R109804 |
迷迭香酸 |
分析标准品,≥97% |
20283-92-5 |
10mg,20mg |
|
IKK-β |
|
R109805 |
迷迭香酸 |
97% |
20283-92-5 |
1g,5g |
|
IKK-β |
|
W167241 |
WS3 |
98% (HPLC) |
1421227-52-2 |
5mg,25mg |
|
IκB |
|
*NOD1
项目号 |
产品名称 |
规格 |
CAS |
包装 |
靶点 |
IC50 |
M129713 |
ML130 (Nodinitib-1) |
≥99% |
799264-47-4 |
5mg,10mg,25mg,50mg |
NOD1 |
0.56 μM |
|