The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added. Store at 2-8C.<br>The biotin (BIOT) conjugate is supplied as 0.5 mg
克隆性:
单克隆
适应物种:
Mouse
库存:
大量
供应商:
genway
应用范围:
Flow Cytometry (FACS), IHC-F
抗体英文名:
Rat Anti-Mouse LPAM-1 (Integrin 47), Antibody
规格:
0.2 mg
Similarity: Contains 7 FG-GAP repeats. 1. Andrew, D. P., C, Berlin, S. Honda, T. Yoshino, et al. 1994. J. Immunol. 1533847.
Function: Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. Mice homozygous for a null mutation of the alpha-4 subunit gene die by day E11-E14 from detachment and rupture of the epicardium and coronary arteries.