A synthetic phosphorylated peptide around S235 & S236 of human RPS6 (NP_001001.2).
Sequence
LSSL
Gene ID
6194
Swiss Prot
P62753
Synonyms
RPS6; S6; ribosomal protein S6
Category
eIF4E and p70 S6K pathway; MAPK/Erk in Growth & Differentiation; PI3K/Akt Signaling; mTOR Signaling
Background
One way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation. Growth factors and mitogens induce the activation of p70 S6 kinase and the sub sequent phosphorylation of the S6 ribosomal protein (RPS6). Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions. These particular mRNA transcripts (5'TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation. Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of the S6 protein.