Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
适应物种:
Human
库存:
100
宿主:
Rabbit
应用范围:
WB, FC, E
靶点:
This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 amino acids from the N-terminal region of human AKR1C3.
抗体名:
DDH1, HSD17B5, KIAA0119, PGFS
规格:
100 μl
分子量:
36853 Da
细胞定位:
Antigen Cellular Localization:Cytoplasm.
形式:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :Zakharov, V., et al. Int J Clin Exp Pathol 3(6):608-617(2010)
产品概述:
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality AKR1C3 antibody (N-term).
功能:
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
总结:
This gene encodes a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. These enzymes catalyze the conversion of aldehydes andketones to their corresponding alcohols by utilizing NADH and/orNADPH as cofactors. The enzymes display overlapping but distinctsubstrate specificity. This enzyme catalyzes the reduction ofprostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and theoxidation of 9alpha,11beta-PGF2 to PGD2. It may play an importantrole in the pathogenesis of allergic diseases such as asthma, andmay also have a role in controlling cell growth and/ordifferentiation. This gene shares high sequence identity with threeother gene members and is clustered with those three genes atchromosome 10p15-p14.
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