产品货号:jlcR19282 英文名称 :NLRC3 中文名称 :凋亡加强结构域蛋白15样蛋白抗体 别 名 :CARD15-like; CARD15-like protein; Caterpiller 16.2; Caterpiller protein 16.2; CLR16.2; FLJ00348; NLR family, CARD domain containing 3; Nlrc3; NLRC3_HUMAN; NOD-like receptor C3; NOD3; NOD3 protein; Nucleotide-binding oligomerization domain protein 3; Nucleotide-binding oligomerization domain protein 3 caterpiller 16.2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; Protein NLRC3. 研究领域 :细胞生物 结合蛋白 淋巴细胞 t-淋巴细胞 抗体来源 :Rabbit 克隆类型 :Polyclonal 交叉反应 : Human, Mouse, Pig, Cow, Sheep, 产品应用 :ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :115kDa 细胞定位 :细胞浆 性 状 :Lyophilized or Liquid 浓 度 :1mg/ml 免 疫 原 :KLH conjugated synthetic peptide derived from human NLRC3:721-820/1065 亚 型 :IgG 纯化方法 :affinity purified by Protein A 储 存 液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 :Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed :PubMed 产品介绍 : This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Function: May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.
Subcellular Location: Cytoplasm.
Tissue Specificity: Detected in peripheral blood mononuclear cells.
Similarity: Belongs to the NLRP family. Contains 16 LRR (leucine-rich) repeats. Contains 1 NACHT domain.
SWISS: Q7RTR2
Gene ID: 197358
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.