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丁香通研选
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tyrosine kinase, non-receptor, 2
IgG
liquid
12 months -20℃
多克隆
Human, Mouse, Rat
12月
FNab00086
科研
100
武汉菲恩生物科技有限公司
Rabbit
ELISA, WB, IHC
ACK1 antibody
ACK1 antibody
100µg
| 产品名称 | anti- ACK1 antibody | |
| 货号 | FNab00086 | |
| 规格 | 100µg | |
| 状态 | liquid | |
| 纯化方法 | Immunogen affinity purified | |
| 纯度 | ≥95% as determined by SDS-PAGE | |
| 宿主 | Rabbit | |
| 亚型 | IgG | |
| 存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | |
| 背景介绍 | TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd. | |
| 免疫原 | tyrosine kinase, non-receptor, 2 | |
| 别称 | ACOT6; acyl CoA thioesterase 6; c14_5530; C14orf42 | |
| 分子量 | 70 kDa | |
| Uniprot ID | Q07912 | |
| 适用种属 | Human, Mouse, Rat | |
| 验证应用 | ELISA, WB, IHC | |
| 建议稀释比例 | WB: 1:200-1:2000; IHC: 1:20-1:200 | |
| 图片 |  | Immunohistochemistry of paraffin-embedded human breast cancer using FNab00086(ACK1 antibody) at dilution of 1:50 |
 | SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab00086(ACK1 antibody) at dilution of 1:500 | |
| 注意事项 | ACK1 antibody|ACK1抗体仅供科研使用 | |
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2021.01.27-2021.12.31
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