产品名称:重组人N-糖基化酶
英文名称:Recombinant Human N-Glycosylase
产品货号:JN1926
产品规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Gly345在N端带有GST标签。
DNA Lyase质量控制:>95%(还原性SDS-PAGE)
DNA Lyase制剂:液体
DNA Lyase保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于DNA Lyase:
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.