产品英文名称: Recombinant Human Cbp/p300-Interacting Transactivator 2
英文简称: CITED2
中文名称: 重组人Cbp/p300-反式作用因子
背景资料: CITED2 is a significant transcriptional cofactor that takes part in multiple organ development. CITED2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a negative regulator for HIF1A through its competitive binding with HIF1A to CBP/p300. CITED2 is essential for mouse fetal liver hematopoiesis and is necessary for the appropriate formation of the hyaloid vasculature and for lens morphogenesis. CITED2 is a coactivator of HNF4alpha and necessary for liver development. CITED2 is a coactivator of PPAR-alpha and both participate in signaling cascades of hypoxic response and angiogenesis.
产品描述: CITED2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 278 amino acids (1-270 a.a.) and having a molecular mass of 29.5 kDa.The CITED2 is fused to 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌中重组表达
溶解建议: Sterile Filtered colorless solution. The CITED2 solution contains 20mM Tris pH-8, 1mM DTT ,0.1M NaCl & 50% glycerol.
保存建议: CITED2 although stable 4℃ for 4 weeks, should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
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