Product overview
Description Anti-SENP6 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Synthetic peptide of human SENP6
Reactivity Human
Content 1.14 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol SENP6
Full name SUMO1/sentrin specific peptidase 6
Synonyms SSP1; SUSP1
Swissprot Q9GZR1
Target Background
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Anti-SENP6 antibody Applications
Western blotting
Predicted band size:126 kDa
Positive control:Human prostate tissue lysate
Recommended dilution: 500-2000