Product overview
Description Anti-KCNT1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human KCNT1
Reactivity Human, Mouse, Rat
Content 0.9 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol KCNT1
Full name potassium sodium-activated channel subfamily T member 1
Synonyms ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2
Swissprot Q5JUK3
Target Background
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml264334(KCNT1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)