Product overview Description Anti-KCNN2 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human KCNN2
Reactivity Human, Mouse, Rat
Content 1.86 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol KCNN2
Full name potassium calcium-activated channel subfamily N member 2
Synonyms SK2; hSK2; SKCA2; KCa2.2; SKCa 2
Swissprot Q9H2S1
Target Background Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants.