一种脂质类激酶的泛素I类PI3K(磷脂酰肌醇3-激酶)抑制剂,作用于p110α、p110β、p110δ和p110γ,IC50分别为52nM、166nM、116nM和262nM。Buparlisib is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. PI3K inhibitor BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway。