一种紫杉类抗癌药物,它结合并稳定微管蛋白亚基,有丝分裂纺锤体的解聚,从而导致细胞周期阻滞和凋亡。在MCF7、A549、KB、A121、HT-29、HCT-116和OVCAR-3的IC50分别为1nM、1nM、0.1nM、1.2nM、1.2nM、1.2nM和1.2nM。Docetaxel is a semi-synthetic analog of the famous microtubule-stabilizing small molecule Taxol. These taxane compounds prevent the breakdown of microtubules necessary for mitotic progress, arresting the cell cycle at G2/M, leading to apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation。