品牌:miltenyi,产品名称:CD3-PE, mouse CD3 antibodies, mouse - Miltenyi Biotec 货号:130-109-837 Clone REA641 recognizes the mouse CD3 complex, which is expressed on all mature T lymphocytes, NKT cells and during the development of thymocytes. CD3, also known as T3, belongs to the Ig superfamily. It consists of CD3ε, δ, γ and ζ chains and forms a TCR complex by associating with TCR α/β or γ/δ chains. The TCR does not possess intracellular signaling domains, uncoupling Ag recognition from T cell signaling. The TCR is instead noncovalently associated with a multisubunit signaling apparatus, consisting of the CD3εγ and CD3εδ heterodimers and the CD3ζζ homodimer, which collectively form the TCR-CD3 complex. CD3 is involved in T cell activation, signal transduction, and antigen recognition by binding the peptide/MHC antigen complex. Additional information: Clone REA641 displays negligible binding to Fc receptors.